MAB Designs Pipeline


LITERATURE

IL-6 TRANS SIGNALLING

Targeting IL-6 trans-signalling: past, present and future prospects.
Rose-John S, Jenkins BJ, Garbers C, Moll JM, Scheller J. Nat Rev Immunol. (2023) Apr 17:1–16. doi: 10.1038/s41577-023-00856-y. PMID: 37069261; PMCID: PMC10108826.

Blocking only the bad side of IL-6 in inflammation and cancer.
Stefan Rose-John ; Cytokine 148 (2021) 155690 https://doi.org/10.1016/j.cyto.2021.155690

Interleukin-6: From basic biology to selective blockade of pro-inflammatory activities.
Jürgen Scheller, Christoph Garbers, Stefan Rose-John: Seminars in Immunology 26 (2014) 2–12 http://dx.doi.org/10.1016/j.smim.2013.11.002

Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain.
Iain L Campbell 1, Maria Erta, Sue Ling Lim, Ricardo Frausto, Ulrike May, Stefan Rose-John, Jürgen Scheller, Juan Hidalgo. J Neurosciences. 2014 Feb 12;34(7):2503-13. doi: 10.1523/JNEUROSCI.2830-13.2014.

MESOTHELIN

A new anti-mesothelin antibody targets selectively the membrane-associated form.
Asgarov K, Balland J, Tirole C, Bouard A, Mougey V, Ramos D, Barroso A, Zangiacomi V, Jary M, Kim S, Gonzalez-Pajuelo M, Royer B, de Haard H, Clark A, Wijdenes J, Borg C. MAbs. 2017 Apr;9(3):567-577. doi:10.1080/19420862.2017.1288770.

SYNDECAN-1

A plasmocyte selective monoclonal antibody (B-B4) recognises syndecan-1.
John Wijdenes etc All, British Journal of Haematology, 1996, 94, 318-323

IL-2 RECEPTOR

Treatment of Acute Graft-versus-Host disease with monoclonal antibody to IL-2 Receptor.
P. Hervé and John Wijdenes, Letters to the Editor, the Lancet, Nov 5, 1988, 1072-1073

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